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Low-dose bevacizumab plus atezolizumab enhances transarterial chemoembolization in HCC via correcting vascular-immune niche dysfunction
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DOI:10.1016/j.jhep.2026.07.028.png)
Abstract
En 中文
• TACE induces a hypoxic vascular niche featuring immature vasculature and an immunosuppressive TME. • TACE enriches PDGFC+ TAMs with pro-angiogenic and immunosuppressive phenotypes, linked to poor prognosis. • PDGFC+ TAMs orchestrate a positive feedback loop of pericyte-to-CAF transition and CAF activation. • Low-dose bevacizumab plus atezolizumab promotes vascular normalization and antitumor immunity after TACE.
Journal
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Citations:
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