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Low-level tetrabromobisphenol a (TBBPA) exposure disrupts early embryonic architecture: molecular impacts on dorsoventral patterning
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DOI：10.1016/j.cbpc.2025.110348.png)
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Abstract
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• TBBPA exposures ventralize embryos and increase BMP signaling • TBBPA perturbs protein markers of epithelial-to-mesenchymal transition, germ layers and neural crest cells • TBBPA defects in cartilage development and blood cell development at environmentally realistic concentrations • BMP inhibitor does not rescue the phenotypes, suggesting limited role of BMP
Keywords:
TBBPA
Dorsoventral patterning
BMP signaling
Zebrafish
Gastrulation
Organogenesis
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