Low Post-Treatment Recurrence After a Shortened All-oral Regimen for Pulmonary Rifampicin- or Multidrug-Resistant Tuberculosis in Individuals without Prior Second-Line Drug Exposure in Kazakhstan

2026-07-01

Edmund Shen, BA *

Yerkebulan Algozhin

Letizia Trevisi, PhD

Allison LaHood, MS

Elena Algozhina

Nataliya Arlyapova

Kwonjune Justin Seung, MD

Carole D Mitnick, ScD

Michael L Rich, MD, MPH

Molly F Franke, ScD

Makhmujan Rashitov *

DOI：10.1093/cid/ciag391

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We conducted a prospective cohort study of adults with pulmonary MDR/RR-TB in Kazakhstan treated with one of three all-oral, five-drug regimens. Individuals were followed microbiologically and clinically for up to 12 months post-treatment. Of 578 with favorable end-of-treatment outcomes, we observed only one incident case of recurrent TB (0.2%, 95%CI: 0.0-1.0%), suggesting excellent regimen durability under programmatic conditions.

Low Post-Treatment Recurrence After a Shortened All-oral Regimen for Pulmonary Rifampicin- or Multidrug-Resistant Tuberculosis in Individuals without Prior Second-Line Drug Exposure in Kazakhstan

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