Lower expression of BRCA1 in cardiomyoblast alters the expression of apoptotic, inflammatory and metabolic pathway genes, and enhances catecholamine-induced hypertrophic response

Ubaid Tariqa

doi:10.1016/j.gene.2026.150249

Lower expression of BRCA1 in cardiomyoblast alters the expression of apoptotic, inflammatory and metabolic pathway genes, and enhances catecholamine-induced hypertrophic response

2026-06-02

0

PRE

AI

U

Ubaid Tariqa

S

Soumalya Sarkar

R

Roshan Kumara

S

Samhita Chakraborty

P

Paramesha Bugga

P

Praloy Chakraborty

S

Sanjay K Banerjeea *

DOI：10.1016/j.gene.2026.150249

Original

Original request for help

Save

Abstract

En 中文

• BRCA1 regulates apoptosis, inflammation, metabolism and hypertrophy-related gene expression in cardiomyoblasts. • Lentiviral knockdown of BRCA1 increases cardiomyoblast susceptibility to hypertrophy, fibrosis, and remodeling upon isoproterenol exposure.

Lower expression of BRCA1 in cardiomyoblast alters the expression of apoptotic, inflammatory and metabolic pathway genes, and enhances catecholamine-induced hypertrophic response

Abstract

Journal

Organization