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Lrp10 insufficiency upregulates mRNA and protein of neurotoxic α-synuclein and causes degeneration of substantia nigra dopaminergic neurons in heterozygous or homozygous Lrp10 knockout mice
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DOI：10.1016/j.neuint.2026.106186.png)
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Abstract
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• Lrp10+/- mouse is animal model of LRP10 haploinsufficiency-induced PD. • Lrp10+/- mice display PD motor impairment and demise of SN dopaminergic neurons. • Lrp10 deficiency elevated α-synuclein mRNA and protein in SN of Lrp10+/- mice. • Lrp10 insufficiency activates SN ER stress and mitochondrial apoptotic cascades. • Lrp10 deficiency causes activation of microglia and microglial NLRP3 inflammasome.
Keywords:
LRP10
α-synuclein
substantia nigra
dopaminergic neurons
neurodegeneration
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