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Lumican-Mediated Fibroblast Differentiation in Skin Fibrosis
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DOI：10.1016/j.matbio.2026.03.006.png)
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Abstract
En 中文
• Lumican is a key regulator of fibroblast differentiation. • Lumican-mediated fibroblast differentiation drives pathological scarring. • Lumican downregulation suppresses keloid hyperplasia in 3D human organoids and nude mouse models.
Keywords:
Fetal scarless healing
Fibroblast
Differentiation
Single-cell RNA sequencing
Spatial transcriptomics
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