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Lycorine hydrochloride reveals a novel role in preventing neointimal hyperplasia through MAPK-mediated phenotypic switching of smooth muscle cells

delete2026-04-28
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PRE
AI
D
Dongxu Li
李
李莉 (Li Li)
Y
Yingying Fan
C
Caiyun Lu
N
Nan Feng
C
Chaowei Zhang
J
Ji Gao
S
Siyu Sun
X
Xiulong Wang
X
Xuefang Li
L
Libo Wang
陈
陈志钢 (Zhigang Chen) *
G
Guoan Zhao *
F
Fei Lin *
DOI：10.1016/j.yjmcc.2026.04.008delete
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Abstract

Abstract

En 中文
• Lycorine hydrochloride (LH) inhibits neointimal hyperplasia in vivo. • LH suppresses VSMC phenotypic switching via MAPK pathway inhibition. • Targeted binding of LH to Erk1 in the regulation of VSMC phenotypic switching. • LH shows potential as a pharmacological intervention for restenosis.
Keywords:
Lycorine hydrochloride
neointimal hyperplasia
VSMC phenotypic switching
MAPK pathway
restenosis

Journal

Journal of Molecular and Cellular Cardiology cover
Journal of Molecular and Cellular Cardiology
IF:
4.7
Papers:
9.9K
Citations:
1.4W

Organization

X
xinxiang medical university
Scholars:
242
Papers: 51
Citations: 0
H
henan university
Scholars:
2.2W
Papers: 1.3W
Citations: 20
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