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Lymphatic endothelial cells actively shape immune responses in the lungs
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DOI：10.1016/j.coi.2026.102802.png)
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Abstract
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• Pulmonary lymphatic endothelial cells play previously underappreciated roles in immune regulation. • During inflammation, lung lymphatics remodel their intercellular junctions to enhance fluid uptake. • The cytokine LIF increases CCL21 chemokine release from lung lymphatic endothelial cells, supporting lymphatic clearance of leukocytes from inflamed lungs. • VEGFR-3 activation may alter inflammatory responses in the lungs through both acute effects and through promoting lymphangiogenesis. • Development of therapeutics targeting lung lymphatics will require advances in preclinical and clinical research methods.
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