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Lysosomes join the circular RNA decay machinery
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DOI：10.1016/j.tcb.2026.07.001.png)
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Abstract
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Circular RNAs (circRNAs) are covalently closed, stable RNA molecules with broad physiological functions. Precise regulation of circRNA turnover is essential for cellular homeostasis. A recent study by Deng et al. uncovers an evolutionarily conserved mechanism in which RNAseK and the lysosome act synergistically to degrade circRNAs across metazoans.
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