Macrocyclic-Engineered Supramolecular AIE Photosensitizer for Boosted NIR-II Phototheranostics

doi:10.1002/adfm.77316

Macrocyclic-Engineered Supramolecular AIE Photosensitizer for Boosted NIR-II Phototheranostics

2026-07-27

0

PRE

AI

DOI：10.1002/adfm.77316

Original

Original request for help

Save

Abstract

En 中文

Multimodal phototheranostics on the basis of second near-infrared (NIR-II) aggregation-induced emission (AIE) small molecules has emerged as a promising paradigm for cancer treatment. Nevertheless, beyond molecular design, precise control over aggregation behavior that is critical for tuning optical properties and therapeutic functions, remains challenging. Herein, we report a supramolecular aggregate-engineering strategy that employs pillar[5]arene-mediated host–guest complexation to direct the assembly of NIR-II AIE luminogens. By finely balancing excited state energy dissipation pathways, the resulting supramolecular AIE nanoparticles (PTNI NPs) achieve significantly enhanced performance in multimodal NIR-II fluorescence imaging (FLI)-guided synergistic photodynamic and photothermal therapy of orthotopic 4T1 breast tumors, outperforming their macrocycle-free counterpart. In vivo studies demonstrated that PTNI NPs exhibited prolonged tumor retention and intense NIR-II fluorescence, leading to pronounced tumor growth inhibition and enabling precise fluorescence-guided surgical navigation. This supramolecular assembly approach offers a generalizable route to advanced phototheranostic agents with tailored optical and therapeutic outputs.

Keywords:

aggregation-induced emission

phototheranostics

pillar[5]arene

supramolecular self-assembly

Macrocyclic-Engineered Supramolecular AIE Photosensitizer for Boosted NIR-II Phototheranostics

Abstract

Journal

Organization