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Macromolecular microfluidic concentrators
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DOI：10.1063/5.0116830.png)
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Abstract
En 中文
Microfluidic design, fabrication, and experiments have developed rapidly, leading to lab-on-chip separation or fractionation. In this work, we design a continuous concentrator for macromolecular solutions. Our design relies on the analytical solutions for orientational diffusion under laminar pressure-driven slot flow through a microchannel [W. Stasiak and C. Cohen, Dilute solutions of macromolecules in a rectilinear Poiseuille flow, J. Chem. Phys. 78, 553 (1983)]. Using rigid dumbbell theory, we provide analytical solutions for the design of our microfluidic macromolecular hydrodynamic chromatography. We arrive at our design through the use of well-known confinement-driven composition profiles. Using a pair of razor-sharp blades, our design separates the slot flow into a symmetric core inner slot (concentrated) between two outer slots (diluted). We discover a minimum dimensionless blade leading edge separation for complete fractionation, and that this decreases with confinement and also decreases with dimensionless shear rate. Published under an exclusive license by AIP Publishing.
Keywords:
NEWTONIAN VISCOELASTIC PROPERTIES
DYNAMICS
FLOW
CONFINEMENT
Journal
IF:
4.3
Papers:
2.9W
Citations:
8.0W