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Macrophage Polarization-Inducible Cholesterol Lipid-Assisted Nanoparticles Prime Systemic Antitumor Immunity

delete2026-07-27
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PRE
AI
B
Bofu Ma
M
Miao Su
B
Boya Yu
C
Chaoran Chen
Z
Zhaopeng Wang
B
Bo Liu
X
Xianzhu Yang *
X
Xiaojiao Du *
王军 cover
王军 (Jun Wang) *
DOI：10.1016/j.biomaterials.2026.124488delete
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Abstract

Abstract

En 中文
• A3-Chol@NP induces M1 macrophage polarization and boosts tumor cell phagocytosis. • A3-Chol@NP colocalized with mitochondria in macrophages to generate mtROS. • The mtROS activates NF-κB-iNOS and IRF5-IL-23 pathways, driving M1 polarization. • A3-Chol@NP efficiently suppressed tumor growth via macrophage-mediated immunotherapy.

Journal

Biomaterials cover
Biomaterials
IF:
12.9
Papers:
1.9W
Citations:
10.8W

Organization

G
guangzhou international campus
Scholars:
81
Papers: 15
Citations: 0
S
south china university of technology
Scholars:
6.5W
Papers: 5.0W
Citations: 85
Cited Papers

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