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Macrostructural and microstructural alterations of hippocampal subregions in T2DM: NODDI provides added value to DTI and volumetric analyses

delete2025-06-03
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OA
AI
X
Xuan‐Yi Huang
Z
Ziyu Diao
D
Die Shen
J
Jianyu Li
J
Jiahe Wang
K
Kun Wang
S
Shijun Qiu
DOI：10.1016/j.brainresbull.2025.111417delete
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Abstract

Abstract

En 中文
• NODDI detects microstructural damage in hippocampal subfields of T2DM patients more sensitively than DTI or volume. • DTI and NODDI consistently show that HATA is a key region for microstructural changes in T2DM. • Increased NDI values may reflect compensatory neuroplasticity in T2DM patients to counteract neuronal damage. • Microstructural damage in hippocampal subfields may contribute to cognitive decline in T2DM patients.
Keywords:
T2DM
NODDI
DTI
Microstructure
Hippocampal subregions

Journal

Brain Research Bulletin cover
Brain Research Bulletin
IF:
3.7
Papers:
6.9K
Citations:
1.2W

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No organization information available