.png){kind=icon}
Return
Magnetically Driven Lasing Microrobots for Precise Photodynamic Therapy
.png){kind=icon}
PRE
AI
DOI：10.1021/acsnano.5c15360.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Photodynamic therapy (PDT) is an emerging approach for tumor treatment, valued for its noninvasive and stimuli-responsive properties. However, its therapeutic efficacy is often constrained by unintended damage to healthy tissues, largely due to the strong scattering of pump light within biological media. In this study, we present a magnetically driven lasing microrobot as an effective light source for high-precision localized PDT. The microrobots were constructed from polystyrene microspheres doped with Nile Red and magnetic particles. When pumped with 530 nm light, these microrobots emit strong coherent whispering-gallery-mode (WGM) lasers at approximately 650 nm, matching the absorption of chlorin e6. A 20 mu m microrobot demonstrated a lasing threshold of 52.1 mu J mm-2 and a motion velocity of 78.5 mu m s-2 in biological media. Theoretically, the output power of the microrobot can meet the energy requirements for PDT treatment, while its illumination range reaches 35.1 mu m. Leveraging its motion capabilities, the microrobot can navigate to targeted tumor sites on demand, enabling the precise ablation of tumor cells. PDT efficacy was validated using intestine-on-a-chip models and three-dimensional (3D) intestinal tumor spheroids. Results showed that the spatial resolution for tumor cell ablation reached 651.3 mu m2 in tumor spheroids, highlighting a significant improvement in therapeutic accuracy over conventional PDT approaches. This work integrates microlasers with robotic technology, offering a promising strategy for achieving high-precision PDT.
Keywords:
microlaser
magnetic microrobot
photodynamictherapy
whispering gallery mode
tumor
Journal
IF:
16
Papers:
2.7W
Citations:
25.6W
Organization
View more organizations
Cited Papers
ShareSaveTissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy
PREAI
ShareSaveUltrasensitive Sensor Using Quantum Dots-Doped Polystyrene Nanospheres for Clinical Diagnostics of Low-Volume Serum Samples.png)
ANALYTICAL CHEMISTRY
ANALYTICAL CHEMISTRYIF6.7
PREAI
ShareSaveCompressible Hollow Microlasers in Organoids for High-Throughput and Real-Time Mechanical ScreeningACS NANO
ACS NANOIF16
PREAI
ShareSavePolymeric photosensitizer-embedded self-expanding metal stent for repeatable endoscopic photodynamic therapy of cholangiocarcinomaBIOMATERIALS
BIOMATERIALSIF12.9
PREAI
ShareSaveEngineering bioluminescent bacteria to boost photodynamic therapy and systemic anti-tumor immunity for synergistic cancer treatmentBIOMATERIALS
BIOMATERIALSIF12.9
PREAI
ShareSaveMagnetic nanoparticles embedded in microlasers for controlled transport in different sensing media
PREAI
ShareSaveShareSave
View more