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Maladaptive trained immunity as a hematopoietic stem cell driver of inflammaging
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DOI：10.1038/s43587-026-01197-w.png)
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Abstract
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A new study reveals that aging hematopoietic stem cells trigger a form of innate immune memory, known as trained immunity, that fuels the chronic low-grade inflammation that underlies age-related physiological decline. SIRT3, a mitochondrial deacetylase whose expression wanes with age, emerges as a key molecular brake on this process.
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