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Man-made antibodies and immunoconjugates with desired properties: function optimization using structural engineering
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DOI：10.1070/RCR4459.png)
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Abstract
En 中文
The review outlines progress and problems in the design of non-natural antibodies for clinical applications over the past 10-15 years. The modular structure of natural antibodies and approaches to its targeted modifications and combination with other structural elements and effector molecules are considered. The review covers modern methods for immunoglobulin engineering and promising strategies for the creation and applications of monoclonal antibodies, their derivatives and analogues, including abzymes and scaffolds, oriented to the use in the diagnosis and targeted therapy of cancer and other socially significant diseases.
Keywords:
SINGLE-CHAIN FV
GROWTH-FACTOR RECEPTOR
NEONATAL FC-RECEPTOR
DEPENDENT CELLULAR CYTOTOXICITY
IN-VIVO
ANTIGEN-BINDING
MONOCLONAL-ANTIBODY
BISPECIFIC ANTIBODIES
CATALYTIC ANTIBODIES
IMMUNOGLOBULIN-G
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