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Mannose-guided carrier-free nanodrugs for cascade targeted eradication of intracellular bacterial infections
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DOI：10.1016/j.nantod.2026.103120.png)
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Abstract
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• Carrier-free MTBN enables targeted eradication of intracellular S. aureus. • MTBN achieved 99.99% and 99.9% intracellular bacterial killing in vitro and in vivo, respectively. • MTBN enables cascade delivery, lysosomal escape, and bacterial penetration. • Synchrotron nano-tomography directly verified MTBN entry into bacteria in 3D.
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