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MAPK-driven glioma progression and reprogramming of the tumor-associated immune response

delete2026-06-30
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OA
AI
E
Elaheh Hashemi
R
Ravishkumar Lakshmi Akshaya
L
Lin Wang
S
Spencer Bergland
H
Hadeesha Piyadasa
J
Jolene S Ranek
V
Viva Voong
A
Aditya Kshirsagar
A
Anny Shai
B
Benjamin Oberlton
A
Anupam Kumar
M
Mitchel S Berger
E
Edward F Chang
M
Michael C Oldham
R
Robert M Prins
S
Sean C Bendall
M
Michael Angelo
S
Shawn L Hervey-Jumper
H
Hideho Okada
A
Aaron Diaz
J
Joanna J Phillips *
DOI:10.1093/neuonc/noag147delete
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Abstract

Abstract

En 中文
In brain tumors, the immunosuppressive microenvironment leads to tumor aggressiveness and immunotherapy resistance. To identify factors that regulate the glioma immune landscape, we took advantage of the disease trajectory of the MAPK-driven glioma, pleomorphic xanthoastrocytoma (PXA), which evolves from an immune-rich low-grade tumor to an aggressive glioma.

Journal

N
Neuro-Oncology
IF:
13.4
Papers:
1.2W
Citations:
2.5W

Organization

U
university of california san francisco
Scholars:
5.2W
Papers: 4.0W
Citations: 66
P
Parker Institute for Cancer Immunotherapy
Scholars:
13
Papers: 6
Citations: 2.7K
S
stanford university school of medicine
Scholars:
588
Papers: 183
Citations: 0
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