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Matched sampling reveals uncoupled phenotypic plasticity during metastasis formation in uveal melanoma

delete2026-06-19
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OA
AI
K
Karim Al-Ghazzawi *
S
Sabrina Borchert
S
Siyang Liu
A
Amal R. Al Kadi
F
Fung-Yi Cheung
G
Georgia Antonopoulou
T
Tobias Blau
A
Andreas Junker
L
Leyla Jabbarli
S
Sylvia Hartmann
O
Olaf D. Muras
M
Michael Zeschnigk
T
Tobias Kiefer
K
Kathy Keyvani
M
Michael Wessolly
M
Miltiadis Fiorentzis
U
Utta Berchner-Pfannschmidt
N
Nikolaos Bechrakis
F
Fabian Mairinger *
H
Halime Kalkavan *
DOI：10.1016/j.isci.2026.116397delete
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Abstract

Abstract

En 中文
• RNA-seq identifies two distinct subtypes in each primary and metastatic UM • Matched sampling reveals phenotypic reprogramming during UM metastasis • Immune landscapes shift from adaptive in primary UMs to innate in metastatic UMs • The inflammatory primary UM subtype correlates with worse patient survival
Keywords:
Immune system
Cancer systems biology
Cancer

Journal

iScience cover
iScience
IF:
4.1
Papers:
4.6K
Citations:
4.1W

Organization

G
German Cancer Research Center and University Hospital Essen
Scholars:
5
Papers: 3
Citations: 0
U
university duisburg-essen
Scholars:
331
Papers: 120
Citations: 1
U
university of duisburg-essen
Scholars:
1.4K
Papers: 520
Citations: 1
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