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Matrix Stiffness Disrupts Tight Junction Integrity in Retinal Pigment Epithelial Cells via YAP1-Mediated Autophagy Suppression

delete2026-04-25
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PRE
AI
S
Songtao Wang
Y
Yu Zhang
N
Ning Yang
J
Jinrong Cui
J
Jinsong Zhao *
DOI：10.1016/j.yexcr.2026.115046delete
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Abstract

Abstract

En 中文
• Matrix stiffening disrupts tight junction integrity in retinal pigment epithelial cells • Increased stiffness suppresses autophagic flux and reduces ZO-1, Occludin and Claudin-19 • Autophagy modulation partially rescues stiffness-induced tight junction impairment • YAP1 mediates stiffness-dependent autophagy inhibition in RPE cells • A stiffness–YAP1–autophagy axis regulates outer blood–retinal barrier homeostasis
Keywords:
Matrix stiffness
Tight junction integrity
Autophagy suppression
YAP1
Retinal pigment epithelial cells

Journal

Experimental Cell Research cover
Experimental Cell Research
IF:
3.5
Papers:
1.1W
Citations:
2.0W

Organization

J
Jilin University
Scholars:
8.4W
Papers: 5.5W
Citations: 8.9K
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