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MDK promotes the mast cell activation and pancreatic fibrosis in mice with chronic pancreatitis via MDK-NCL signaling pathway

delete2026-04-22
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PRE
AI
J
Jianbin Xiong
J
Jian Song
X
Xing Jiang
Z
Zhuanzhuan Huang
Y
Yijie Zhang *
DOI：10.1016/j.yexcr.2026.115043delete
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Abstract

Abstract

En 中文
• The abundance of MDK and NCL expression was significantly upregulated in chronic pancreatitis. • MDK knockdown in PSCs suppresses PSC activation and fibrosis, and reduces mast cell activation, proliferation and degranulation. • Neutralization of NCL blocks PSC-induced mast cell activation in co-culture systems. • In vivo knockdown of MDK or NCL alleviates pancreatic damage, fibrosis and immune cell infiltration in CP mice.
Keywords:
MDK
NCL
mast cell activation
pancreatic fibrosis
chronic pancreatitis

Journal

Experimental Cell Research cover
Experimental Cell Research
IF:
3.5
Papers:
1.1W
Citations:
2.0W

Organization

G
Guizhou Medical University
Scholars:
953
Papers: 266
Citations: 2.5K
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