.png){kind=icon}
.png){kind=icon}
Return
Mechanically Matched Silicone Brain Implants Reduce Brain Foreign Body Response
.png){kind=icon}
OA
AI
DOI：10.1002/admt.202000909.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Brain implants are increasingly used to treat neurological disorders and diseases. However, the brain foreign body response (FBR) elicited by implants affects neuroelectrical transduction and long-term reliability limiting their clinical adoption. The mismatch in Young's modulus between silicon implants (approximate to 180 GPa) and brain tissue (approximate to 1-30 kPa) exacerbates the FBR, resulting in the development of flexible implants from polymers such as polyimide (approximate to 1.5-2.5 GPa). However, a stiffness mismatch of at least two orders of magnitude remains. The study introduces 1) the first mechanically matched brain implant (MMBI) made from silicone (approximate to 20 kPa); 2) new microfabrication methods; and 3) a novel dissolvable sugar shuttle to reliably implant MMBIs. MMBIs are fabricated via vacuum-assisted molding using sacrificial sugar molds and are then encased in sugar shuttles that dissolved within 2 min after insertion into rat brains. Sections of rat neocortex implanted with MMBIs, polydimethylsiloxane (PDMS) implants, and silicon implants are analyzed by immunohistochemistry 3 and 9 weeks post-implantation. MMBIs result in significantly higher neuronal density and lower FBR within 50 mu m of the tissue-implant interface compared to PDMS and silicon implants, suggesting that materials mechanically matched to brain further minimize the FBR and can contribute to better implant functionality and long-term reliability.
Keywords:
brain implants
flexible implants
foreign body response
mechanical matching
microfabrication
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
6.2
Papers:
5.2K
Citations:
2.4W