Mechanism and active ingredients of Gancao Qinlian Granules in ameliorating ulcerative colitis:integrated in vivo, in vitro, network pharmacology and untargeted metabolomics investigation

doi:10.1016/j.jep.2026.122263

Mechanism and active ingredients of Gancao Qinlian Granules in ameliorating ulcerative colitis:integrated in vivo, in vitro, network pharmacology and untargeted metabolomics investigation

2026-08-01

0

PRE

AI

M

Maixun Zhu

Y

Yang Zhang

S

Shaoqin Zhai

C

Chunlin Chen

Z

Zhiqiang Yan

L

Lizhi Fu

L

Lanyan Zheng

C

Chao Song

Y

Yuandi Yu *

H

Hongmei Tang *

DOI：10.1016/j.jep.2026.122263

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Abstract

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• Integration of seven methods: LC-MS, network pharmacology, metabolomics, microbiota, molecular docking and animal/cell tests. • Novel metabolism-inflammation axis: GQG reverses the dysregulation of gut microbiota and metabolites in UC mice. • Identified core bioactives: Licoflavone B, Licuroside etc. drive GQG efficacy against UC.

Mechanism and active ingredients of Gancao Qinlian Granules in ameliorating ulcerative colitis:integrated in vivo, in vitro, network pharmacology and untargeted metabolomics investigation

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