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Mechanisms of Tumor Radiosensitization: A Perspective of Nano-Radiotherapy
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DOI：10.1002/wnan.70035.png)
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Abstract
En 中文
Radiotherapy (RT) is one of the cornerstones in cancer treatment, with approximately 50% of patients receiving radiation regimens annually. However, its clinical efficacy is constrained by two persistent challenges: tumor radioresistance and radiation-induced damage to healthy tissues. Recent advances in nanomedicine have yielded innovative nano-radiosensitizers capable of enhancing tumor-specific radiation dose deposition while sparing normal tissues, thereby addressing both limitations simultaneously. Previous advanced reviews have extensively covered intrinsic nanomaterial properties and physicochemical mechanisms of radiosensitization; this review systematically elucidates radiosensitization mechanisms through the lens of RT subprocesses, offering a novel framework to evaluate how specific mechanisms modulate discrete stages of radiation response. It includes increasing radiation dose deposition; lowering antioxidant system level to promote ROS production; collaborating with other ways to promote ROS production; collaborating with the production of exogenous cytotoxic substances; augmenting intrinsic radiosensitivity of cancer cells; stabilizing radiation-induced DNA lesions to suppress repair machinery; and enhancing radiogenic immunogenic cell death to strengthen antitumor immunity. Furthermore, we discuss emerging trends in nanotechnology-driven combination therapies. This systematic perspective advances the rational design of next-generation nano-radiosensitizers and informs personalized radiotherapy protocols.
Keywords:
nano-radiosensitizers
radiosensitization mechanism
radiotherapy sub-processes
Journal
W
IF:
0
Papers:
39
Citations:
3