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Mechanistic Basis for Differential Effects of Interatrial Shunt Treatment in HFrEF vs HFpEF: The RELIEVE-HF trial
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DOI：10.1016/j.jcmg.2025.08.005.png)
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Abstract
En 中文
The RELIEVE-HF trial randomized 508 patients with heart failure (HF) to interatrial shunt-treatment vs placebo-procedure. Randomization was stratified into 2 patient groups with HF with reduced ejection fraction (HFrEF;LVEF≤40%) and HF with preserved EF (HFpEF;LVEF>40%). HF event rates (all-cause death, transplantation/LVAD, HF hospitalization/outpatient worsening) after shunt treatment during 2-year follow-up were directionally opposite: decreased by 51% in HFrEF, increased by 69% in HFpEF.
Keywords:
Heart failure
echocardiography
interatrial shunt
CV
Cardiovascular
EF
Ejection Fraction
GDMT
Guideline directed medical therapy
HF
Heart Failure
HFH
Heart failure hospitalization
HFpEF
Heart Failure with a preserved ejection fraction
HFrEF
Heart failure with a reduced ejection fraction
LAP
Left atrial pressure
LV
Left ventricular
RELIEVE-HF trial
REducing Lung congestion symptoms using the v-wavE shunt in adVancEd Heart Failure
RV
Right ventricular
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