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Mechanistic Insight Into Clathrin-Mediated Endocytosis in Plants
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DOI：10.1111/tra.70040.png)
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Abstract
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Clathrin-mediated endocytosis (CME) is an essential and conserved process in all eukaryotes. Plants, however, have evolutionarily retained remarkable endocytic machinery that distinguishes them from yeast and animals. In plants, CME execution involves the cooperative action of the heterotetrameric Adaptor protein 2 complex (AP-2) and the hetero-octameric TPLATE complex (TPC). Plants furthermore rely on the concerted action of two types of dynamin-related proteins during the final stages of clathrin-coated vesicle formation and do not use the actin cytoskeleton to generate the force to initiate membrane bending. Plants also rely more on phosphorylation and ubiquitination, rather than on canonical linear motifs, to integrate cargo sorting with endocytic dynamics. This review covers the entire process of CME in plants. It emphasizes recent advances in our mechanistic understanding of the process and highlights similarities and differences between plants and other model systems.
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