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Mechanistic insights into fluoride-induced male reproductive injury: The role of Nrf2/FSP1 pathway-mediated ferroptosis
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DOI：10.1016/j.jnutbio.2026.110445.png)
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Abstract
En 中文
• Ferroptosis pathway highly linked to fluoride exposure and male infertility. • Fluoride triggers ferroptosis both in the testicular tissue of SD rats and GC-1 cells. • The Nrf2/FSP1 pathway plays an important role in fluoride-induced male reproductive damage. • Fer-1 & TBHQ intervention partially reverses fluoride's effects, reducing ferroptosis and reproductive harm.
Keywords:
Fluoride
Reproductive damage
Ferroptosis
Nrf2/FSP1 pathway
Testicular tissue
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