.png){kind=icon}
.png){kind=icon}
Return
Mechanistic insights into gelation and rheological behavior of Pluronic F127-based thermoresponsive hydrogels
.png){kind=icon}
PRE
AI
S
H
L
S
S
Y
K
N
Z
DOI：10.1007/s00289-026-06498-z.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Thermoresponsive hydrogels utilize temperature variations to modulate their gelation behavior without the need for external crosslinking agents. Pluronic F127 exhibits temperature-dependent sol-gel transitions and forms gels near physiological temperature, making it highly attractive for biomedical applications such as drug delivery and tissue engineering. Despite its widespread use, the fundamental mechanisms governing its gelation and rheological behavior remain incompletely understood. While existing reviews have addressed micellization and sol-gel transitions independently, there is a lack of comprehensive studies that link these processes to quantitative rheological behavior essential for rational biomaterial design. This review provides an integrated analysis of gelation kinetics, micellization thermodynamics, and viscoelastic properties (G′, G″) of Pluronic F127-based hydrogels. It examines how key factors including temperature, concentration, and intermolecular interactions govern micellar organization, network formation, and viscoelastic response. By synthesizing findings from physicochemical, structural, and rheological studies, this work establishes a mechanistic framework that connects microscopic organization with macroscopic material behavior. The insights presented herein aim to support the rational design of thermoresponsive hydrogels and identify critical knowledge gaps to guide future research in advanced therapeutic biomaterials.
Keywords:
Pluronic F127
Thermoresponsive hydrogels
Micellization
Rheology
Gelation mechanism
Drug delivery
Journal
IF:
4
Papers:
8.5K
Citations:
1.5W
Organization
Cited Papers