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Mechanistic Insights into the Neuroprotective Potential of Gut Microbiota-Derived Urolithins in Alzheimer’s Disease

delete2026-05-02
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PRE
AI
M
Mehdi Alami
H
Hicham Berrougui
M
Mojgan Morvaridzadeh
K
Kaoutar Boumezough
I
Ikram Salih
N
Nada Zoubdane
J
Jamal Oubaouz
O
Oualid Abboussi
K
Khalid Sadki
T
Tamas Fülöp
A
Abdelouahed Khalil *
DOI：10.1016/j.mad.2026.112189delete
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Abstract

Abstract

En 中文
• Urolithins are capable of crossing the blood-brain barrier and modulating key pathways involved in Alzheimer's disease. • Urolithins improve brain oxidative stress and mitochondrial functioning • Urolithins reduce neuroinflammation, decrease tau-pathology, and mediate anti-Alzheimer's disease effects.
Keywords:
Urolithins
Alzheimer's disease
neuroprotection
gut microbiota
oxidative stress

Journal

Mechanisms of Ageing and Development cover
Mechanisms of Ageing and Development
IF:
5.1
Papers:
3.2K
Citations:
7.8K

Organization

U
University of Sherbrooke
Scholars:
1.1W
Papers: 9.4K
Citations: 11
M
mohammed v university
Scholars:
283
Papers: 115
Citations: 0
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