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Mechanistic modeling of lipid nanoparticle (LNP) precipitation via population balance equations (PBEs)

delete2025-09-01
delete0
PRE
AI
S
Sunkyu Shin
C
Cedric Devos
A
Aniket Pradip Udepurkar
P
Pavan Inguva
A
Allan S. Myerson
R
Richard D. Braatz *
DOI：10.1016/j.cej.2025.167786delete
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Abstract

Abstract

En 中文
• A mechanistic model for lipid nanoparticle (LNP) fabrication is developed based on population balance equations (PBEs). • The model successfully reproduces the experimentally measured particle size distribution (PSD) of LNPs. • Three key operational strategies for controlling particle size are analyzed in terms of kinetic processes.

Journal

Chemical Engineering Journal cover
Chemical Engineering Journal
IF:
13.2
Papers:
7.4W
Citations:
48.5W

Organization

No organization information available