.png){kind=icon}
.png){kind=icon}
Return
Mechanochemical Amidation Mediated by 1,1’-Oxalyldiimidazole for the Synthesis of Agrochemicals
.png){kind=icon}
OA
AI
A
R
M
F
J
A
E
DOI：10.1002/chem.71190.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
The synthesis of amide moieties, essential components in both pharmaceuticals and agrochemicals, traditionally involves environmentally hazardous and polluting processes. This study presents a novel mechanochemical method to form amide bond using 1,1’-oxalyl diimidazole (ODI) as activating agent, and evaluates its applicability in synthesizing agrochemicals such as Mepronil, Flutolanil, and Fluxapyroxad at gram-scale. The mechanochemical kinetics underlying the synthesis of the three mentioned compounds was also investigated. The new method was compared with the similar 1,1’-carbonyl diimidazole (CDI)-mediated mechanochemical amidation previously reported. Results demonstrate that ODI-mediated synthesis outperforms in the case of deactivated acids. Energetic considerations and technical process parameters are also discussed to provide quantitative technology assessment. A comprehensive analysis by green chemistry metrics with CHEM21 and DOZNTM 3.0 toolkits, underscores the potential benefits of the mechanochemical approach, compared with the solvent-based protocols for the preparation of marketed agrochemicals.
Keywords:
1,1’-carbonyl diimidazole (CDI)
1,1’-oxalyl diimidazole (ODI)
agrochemicals
amide bond
ball-milling
energy
green metrics
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
C
IF:
3.7
Papers:
1.1K
Citations:
20
Organization
Cited Papers