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Mechanoregulating HA-integrated anisotropic fibrous vessel promote AKT-sensitive and YAP-associated endothelial responses and improve regional lymphatic drainage in lymphedema
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DOI：10.1016/j.biomaterials.2026.124498.png)
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Abstract
En 中文
• Electrospun artificial lymphatic vessels for functional lymphedema therapy. • Micropatterned PCL/HA fibrous vessel for effective lymphatic drainage. • HA activates AKT-sensitive and YAP-associated response in LEC. • Scaffold topography regulates LEC mechanotransduction and lymphangiogenesis. • Implantation restores lymphatic drainage and reduces edema in vivo.
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12.9
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1.9W
Citations:
10.8W
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