MeCP2 in the nucleus accumbens regulates operant cocaine self-administration and effort-based responding

Jinhee Bae

doi:10.1016/j.pbb.2026.174167

MeCP2 in the nucleus accumbens regulates operant cocaine self-administration and effort-based responding

2026-02-08

0

PRE

AI

J

Jinhee Bae

S

Sujin Ahn

S

Sangjoon Lee

Y

Yong Sik Kim

H

Heh-In Im *

DOI：10.1016/j.pbb.2026.174167

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Abstract

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• NAc MeCP2 knockdown increases operant cocaine self-administration at the unit dose tested. • shMeCP2 mice show higher cocaine infusions and active lever responding than controls during the maintenance phase and under a progressive-ratio schedule. • NAc MeCP2 knockdown does not alter baseline locomotion, anxiety-like behavior, or food-reinforced operant performance. • CPP-assessed cocaine-conditioned reward does not differ between groups under matched passive cocaine exposure (single dose).

Keywords:

MeCP2

nucleus accumbens

cocaine self-administration

operant behavior

effort-based responding

MeCP2 in the nucleus accumbens regulates operant cocaine self-administration and effort-based responding

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