.png){kind=icon}
.png){kind=icon}
Return
Mediating Cross-Talk: How Uterus-Derived Extracellular Vesicles Influence Early Embryo Development and Implantation
.png){kind=icon}
OA
AI
Q
L
B
DOI：10.1017/erm.2026.10034.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
BackgroundBlastocyst formation represents an essential requirement for subsequent implantation. Successful embryo implantation depends on adequate endometrial receptivity and appropriate embryo-maternal communication. Uterus-derived extracellular vesicles (EVs); as biological nanoscale particles carrying non-coding RNAs (nc-RNAs); DNAs; proteins and lipids; play a crucial role in promoting cellular interactions and regulating maternal-foetal dialogue.MethodThis article systematically searched the PubMed database and used the following keyword combinations for literature screening : (exosome * OR ‘extracellular vesicle’) AND (uter OR blastocysti) AND (blastocyst OR embryo*).ResultThe composition of uterus-derived EVs exhibits variation across different physiological periods and plays different roles. Compared with the proliferative phase; EVs during the peri-implantation period contain more molecules related to cell differentiation; cell cycle; cell migration and invasion; apoptosis and antioxidant activity. The EVs discovered from uterine fluid; primary human endometrial epithelial cells (EECs); endometrial stromal cell and so forth have been shown to be internalised by embryos and trophoblast cell. The cargoes carried by EVs; mainly miRNA and proteins; regulate embryonic development and invasion-related pathways or molecules; supporting blastocyst formation and implantation. Similarly; EVs collected from dysfunctional uterus have been proved to disrupt critical reproductive processes; impairing both embryo development and implantation potential.ConclusionThis review summarises the multiple effects of uterus-derived EVs on successful embryo implantation; including the effects on pre-implantation embryo development and embryo implantation ability.
Keywords:
embryo–endometrium crosstalk
embryo implantation
embryonic development
extracellular vesicles
miRNA
reproductive disorders
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
5.5
Papers:
76
Citations:
2.2K
Organization
Cited Papers