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Medulloblastoma Immune Microenvironment Resembles Early Brain Development and Reveals Novel Basophil-B Cell Associated Signatures
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DOI:10.1093/noajnl/vdag134.png)
Abstract
En 中文
Medulloblastoma is the most common malignant pediatric brain tumor, yet the mechanisms underlying immune evasion remain poorly understood. Since the developing brain’s immune environment naturally promotes tissue tolerance and remodeling, we hypothesized that medulloblastoma may exploit developmental immune programs to escape surveillance. Here, we aimed to characterize the immune microenvironment of medulloblastoma compared to healthy brain tissue across different developmental stages.
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