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Medulloblastoma Immune Microenvironment Resembles Early Brain Development and Reveals Novel Basophil-B Cell Associated Signatures

delete2026-06-11
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OA
AI
G
Guy Dumanis
D
Dvir Aran
R
Ruty Mehrian-Shai *
DOI:10.1093/noajnl/vdag134delete
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Abstract

Abstract

En 中文
Medulloblastoma is the most common malignant pediatric brain tumor, yet the mechanisms underlying immune evasion remain poorly understood. Since the developing brain’s immune environment naturally promotes tissue tolerance and remodeling, we hypothesized that medulloblastoma may exploit developmental immune programs to escape surveillance. Here, we aimed to characterize the immune microenvironment of medulloblastoma compared to healthy brain tissue across different developmental stages.

Journal

N
Neuro-Oncology Advances
IF:
4.1
Papers:
1.5K
Citations:
3.2K

Organization

R
Reichman University
Scholars:
1.0K
Papers: 1.1K
Citations: 5
T
tel-aviv university
Scholars:
287
Papers: 109
Citations: 0
T
technion – israel institute of technology
Scholars:
74
Papers: 32
Citations: 0
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