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Meis1 and Meis2 are jointly required for advanced stages of mouse lens morphogenesis
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DOI：10.1016/j.ydbio.2026.04.006.png)
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Abstract
En 中文
• FoxE3-Cre deletion of Meis1/2 from E10.5 reveals post-placodal lens roles. • E12.5 marks onset of epithelial disorganization with lens hypoplasia in double KOs. • Elevated apoptosis and aberrant fiber-cell cycling impair lens growth. • Meis1/2 maintain Pax6/FoxE3/Sox1; Sox2 becomes ectopic in lens epithelium. • Central ZO-1 loss and αSMA induction precede triangular, detached lenses. • Single KOs diverge: Meis1 variable “big eye”; Meis2 largely normal.
Keywords:
Meis1
Meis2
lens morphogenesis
Pax6
FoxE3
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2.1
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393
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2.2W
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