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Melanoma exosomal hsa-miR-221-5p suppresses keratinocyte LL-37 to promote tumor progression

delete2026-08-12
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OA
AI
Q
Quan Sun
G
Ge Peng *
Z
Ziyou Wu
L
Lixia Cui
W
Wanchen Zhao
A
Alafate Abudouwanli
M
Mengyao Yang
S
Shan Wang
Y
Yi Tan
H
Hideoki Ogawa
K
Ko Okumura
F
François Niyonsaba *
DOI:10.1016/j.celrep.2026.117837delete
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Abstract

Abstract

En 中文
• Melanoma locally suppresses LL-37 in tumor-proximal epidermis of clinical specimens • Melanoma exosomal hsa-miR-221-5p represses keratinocyte LL-37 • Keratinocyte LL-37 suppresses melanoma progression • Keratinocyte LL-37 remodels melanoma immune microenvironment
Keywords:
LL-37
Melanoma
Keratinocytes
Exosomes
Tumor microenvironment
CP: cancer
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Journal

Cell Reports cover
Cell Reports
IF:
6.9
Papers:
1.7W
Citations:
10.2W

Organization

T
third military medical university
Scholars:
470
Papers: 97
Citations: 0
H
hainan medical university
Scholars:
6.6K
Papers: 3.6K
Citations: 10
J
juntendo university
Scholars:
2.1K
Papers: 605
Citations: 0
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