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Menin-dependent megakaryocyte proliferation and fibrosis in myeloproliferative neoplasms

delete2026-07-09
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OA
AI
J
Jeremy Wen
A
Anitria Cotton
R
Rashid Mehmood
M
Man Mohan
T
Trent Hall
A
Amber L. Broadhurst
K
Kevin Zhang
Y
Yunusa Olufadi
G
Guolian Kang
B
Bridget Marcellino
J
John Mascarenhas
R
Ronald Hoffman
L
Laura J. Janke
S
Sandeep Gurbuxani
G
Gerard M. McGeehan
J
John D. Crispino *
DOI：10.1016/j.ccell.2026.06.008delete
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Abstract

Abstract

En 中文
• Menin inhibition suppresses megakaryopoiesis via downregulation of MEF2C and MEIS1 • Menin inhibition selectively affects megakaryocyte progenitors • Menin inhibitor revumenib has anti-tumor activity in pre-clinical models of the MPNs
Keywords:
menin
myeloproliferative neoplasms
revumenib
megakaryocyte

Journal

Cancer Cell cover
Cancer Cell
IF:
44.5
Papers:
413
Citations:
5.6W

Organization

I
icahn school of medicine
Scholars:
33
Papers: 15
Citations: 2
U
university of chicago
Scholars:
4.4W
Papers: 3.7W
Citations: 80
S
St. Jude Children's Research Hospital
Scholars:
623
Papers: 167
Citations: 1.6W
S
syndax pharmaceutics, inc.
Scholars:
2
Papers: 1
Citations: 0
Cited Papers

Cited Papers

Citing Papers

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