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Meniscal tissue engineering: Bridging clinical needs and experimental innovation

delete2026-07-10
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Saijiao Lan
H
Hongmei Liu *
吴德成 (Decheng Wu) *
DOI:10.1016/j.jot.2026.101164delete
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Abstract

Abstract

En 中文
Meniscal injuries significantly impact knee function and pose clinical challenges globally. Conservative treatment and surgery are currently the more commonly used treatments, and there are still long-term joint problems such as incomplete meniscus healing and knee pain. Tissue engineering presents a promising alternative by using biomaterials, cellular therapies, and bioactive factors to repair meniscal damage. Despite the promising preclinical results, clinical applications still face challenges such as insufficient biomechanical strength, weak regenerative ability, or low durability. This review seeks to bridge clinical needs with engineering strategies by providing a comprehensive understanding of meniscal structure and function, as well as current treatments and their limitations. We aim to offer new insights to support the development of meniscus products in tissue engineering, thereby helping to lay a theoretical foundation for more accessible therapeutic solutions. Furthermore, we summarize recent advances in meniscus product research from both material and manufacturing perspectives within our laboratory.
Keywords:
Meniscus anatomy
Meniscal pathology
Meniscal repair
Tissue engineering
Regenerative medicine
Three-dimensional printing
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Journal

Journal of Orthopaedic Translation cover
Journal of Orthopaedic Translation
IF:
7.8
Papers:
1.1K
Citations:
4.1K

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