Menopausal hormone therapy, migraine history, and headache severity: Results from the Women's Health Initiative Hormone Therapy clinical trials

doi:10.1111/head.70168

Menopausal hormone therapy, migraine history, and headache severity: Results from the Women's Health Initiative Hormone Therapy clinical trials

2026-08-20

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PRE

AI

Janet W. Rich-Edwards ScD

A

Aladdin H. Shadyab PhD

JoAnn E. Manson MD, DrPH

DOI：10.1111/head.70168

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Abstract

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The aim of this study was to evaluate the association of oral menopausal hormone therapy (estrogen only [E-only] or estrogen and progestin [E+P]), as compared to placebo on postmenopausal headache severity among females with and without a history of migraine in the Women's Health Initiative Hormone Therapy (WHI-HT) trials.

Keywords:

epidemiology

headache

hormone therapy

migraine

randomized control trial

Menopausal hormone therapy, migraine history, and headache severity: Results from the Women's Health Initiative Hormone Therapy clinical trials

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