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Meta-analysis of blood metabolomics reveals dysregulated amino acid, neurotransmitter, and energy pathways in depression

delete2026-05-08
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PRE
AI
A
Aleksandra Panina
A
Aleksandr V. Sokolov
M
Mikhail M. Khandokhin
N
Nikolay Oskolkov
R
Robert Fredriksson
H
Helgi B. Schiöth *
DOI：10.1016/j.pnpbp.2026.111737delete
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Abstract

Abstract

En 中文
• Amino acids, ketone bodies, and Krebs' cycle intermediates are enriched in depression. • Asparagine and glycine are significantly altered in depression. • Neurotransmitter imbalance and excitatory-inhibitory cycles contribute to depression. • Energy and nitrogen metabolism are dysregulated in depression.
Keywords:
amino acids
neurotransmitter imbalance
energy metabolism
Krebs' cycle
depression

Journal

P
Progress in Neuro-Psychopharmacology and Biological Psychiatry
IF:
3.9
Papers:
6.6K
Citations:
1.4W

Organization

U
uppsala university
Scholars:
3.7W
Papers: 3.4W
Citations: 47
L
Latvian Institute of Organic Synthesis
Scholars:
66
Papers: 24
Citations: 0
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