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Metabolic engineering of Saccharomyces cerevisiae for efficient production of dihydroartemisinic acid
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DOI：10.1016/j.biortech.2026.134823.png)
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Abstract
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• Dihydroartemisinic acid-produced Saccharomyces cerevisiae strain was constructed. • AaDbr2-ALDH1 fusion strategy increases DHAA/AA ratio from 0.6 to 4.2. • Cofactor and P450 complex optimization improved DHAA production by 9.3%. • Carbon source regulation decouples growth from DHAA production. • Fed-batch fermentation achieved the highest DHAA titer to 6.8 g/L to date.
Keywords:
Dihydroartemisinic acid
Saccharomyces cerevisiae
metabolic engineering
cofactor optimization
fed-batch fermentation
Journal
IF:
9
Papers:
3.2W
Citations:
17.3W
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