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Metabolic fate and oral dosing feasibility of the formyl peptide receptor 2 agonist WKYMVm: An integrated analytical and kinetic modeling approach
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DOI：10.1016/j.ejps.2026.107578.png)
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Abstract
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• LC-MS/MS method was developed for WKYMVm quantification in biomatrices. • LC-QTOF-MS with MSE identified sequentially truncated metabolites of WKYMVm. • Kinetic modeling pinpointed the Lys-Tyr bond as the primary metabolic soft spot. • Integrated modeling projected the limited oral dosing feasibility for WKYMVm.
Keywords:
WKYMVm
LC-MS/MS
Metabolite profiling
Peptide pharmacokinetics
Metabolic stability
Kinetic modeling
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