.png){kind=icon}
Return
Metabolic Modulation in Macrophage effector Function
.png){kind=icon}
OA
AI
DOI：10.3389/fimmu.2018.00270.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic pathways generating energy and biosynthetic precursors required for growth and general cellular maintenance. However, growing literature provides evidence of a much broader role for metabolic reactions and processes in controlling immunological effector functions. Much of this research into immunometabolism has focused on macrophages, cells that are central in pro- as well as anti-inflammatory responses-responses that in turn are a direct result of metabolic reprogramming. As we learn more about the precise role of metabolic pathways and pathway intermediates in immune function, a novel opportunity to target immunometabolism therapeutically has emerged. Here, we review the current understanding of the regulation of macrophage function through metabolic remodeling.
Keywords:
macrophage
immunometabolism
glycolysis
tricarboxylic acid cycle
electron transport chain
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
5.9
Papers:
5.0W
Citations:
22.7W
Organization
Cited Papers
ShareSaveMetabolic and Nutritional Support of the Enterocutaneous Fistula Patient: A Three‐Phase Approach
PREAI
ShareSaveShareSaveShareSaveShareSaveA dysregulated interleukin-18–interferon-γ–CXCL9 axis impacts treatment response to canakinumab in systemic juvenile idiopathic arthritis.png)
Rheumatology
RheumatologyIF0
PREAI
ShareSaveShareSave
View more