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Metal Oxide Nanoparticles Encapsulated in Porous Polymer Microparticles for Modulation of Hydrogen Sulfide Concentrations
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DOI：10.1016/j.colsurfa.2026.140689.png)
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Abstract
En 中文
Hydrogen sulfide (H2S) is an important gasotransmitter that modulates inflammatory responses in the colon, but elevated levels have been reported to contribute to the onset and progression of colorectal cancer. Current treatments to regulate bacterially produced H2S concentrations include bismuth subsalicylate and antibiotics; however, they pose adverse side effects. This work presents an approach to reduce H2S concentrations using poly(methyl methacrylate)/copper oxide (PMMA/CuO) particles. PMMA microparticles encapsulating CuO nanoparticles were synthesised using a water-in-oil-in-water double emulsion method, leveraging PMMA’s biocompatibility and CuO’s affinity for H2S. By tuning the CuO nanoparticle loading, H2S concentrations could be reduced to biologically relevant levels within 30 min, as quantified by the methylene blue assay. CuO nanoparticles were retained within the PMMA microparticles as confirmed by inductively coupled plasma mass spectroscopy. The PMMA/CuO particles have minimal toxicity and showed efficacy in reducing H2S produced by Fusobacterium nucleatum, a H2S-producing bacterium associated with the development of colorectal cancer. These findings highlight PMMA/CuO microparticles as a promising candidate for reducing elevated H2S levels in bowel conditions such as colorectal cancer.
Keywords:
Hydrogen sulfide
Copper oxide
Poly(methyl methacrylate)
Fusobacterium nucleatum
Colorectal cancer
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