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Metastability in Senescence
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DOI：10.1016/j.tics.2017.04.007.png)
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Abstract
En 中文
The brain during healthy aging exhibits gradual deterioration of structure but maintains a high level of cognitive ability. These structural changes are often accompanied by reorganization of functional brain networks. Existing neurocognitive theories of aging have argued that such changes are either beneficial or detrimental. Despite numerous empirical investigations, the field lacks a coherent account of the dynamic processes that occur over our lifespan. Taking advantage of the recent developments in whole-brain computational modeling approaches, we hypothesize that the continuous process of aging can be explained by the concepts of metastability - a theoretical framework that gives a systematic account of the variability of the brain. This hypothesis can bridge the gap between existing theories and the empirical findings on age-related changes.
Keywords:
AGE-RELATED-CHANGES
STATE FUNCTIONAL CONNECTIVITY
ALZHEIMERS-DISEASE
WHITE-MATTER
BRAIN NETWORKS
OLDER-ADULTS
DEFAULT-MODE
AGING BRAIN
LIFE
ORGANIZATION
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