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Metathesis Depolymerization of a Fluorogenic Self-Immolative Polymer
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DOI：10.1021/acsmacrolett.5c00192.png)
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Abstract
En 中文
We report a self-immolative polymer (SIP) that generates a fluorescent response upon metathesis depolymerization. Functionally distinct from other degradable polymers, SIPs offer the ability to release many subunits per one signal molecule, making them advantageous for a variety of applications such as molecular detection and signal amplification. Utilizing robust copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) chemistry to orthogonally functionalize alkynes, fluorophore coumarin and quencher 4-((4-(dimethylamino)phenyl)azo) (DABCYL) were efficiently installed as side chains on the SIP. The depolymerization mediated by Grubbs 3rd-generation (G3) organoruthenium initiator enabled a fluorescence turn-on response under nanomolar SIP concentrations. To demonstrate the utility of the fluorogenic SIP, we showed a temperature-dependent fluorescence turn-on of this metathesis-triggered SIP using a thermally responsive Grubbs 2nd-generation (G2) organoruthenium initiator.
Keywords:
ACYCLIC DIENE METATHESIS
DRUG-DELIVERY
CATALYSTS
MONOMER
Journal
IF:
5.2
Papers:
340
Citations:
1.4W
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