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Metformin attenuates lens epithelial cell senescence by suppressing cGAS-STING via SIRT1-PGC-1α-mediated mitochondrial fission
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DOI：10.1016/j.exger.2026.113157.png)
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Abstract
En 中文
• Metformin delays UVB-induced LEC senescence by attenuating excessive mitochondrial fission. • Metformin targets SIRT1-PGC-1α pathway to regulate mitochondrial fission. • Inhibiting excessive mitochondrial fission attenuates senescence via cGAS-STING suppression. • Metformin attenuates LEC senescence through SIRT1-PGC-1α-cGAS-STING pathway. • These findings suggest a potential approach for ARC prevention and treatment.
Keywords:
Age-related cataract
Metformin
Mitochondrial fission
SIRT1-PGC-1α
cGAS-STING
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