.png){kind=icon}
.png){kind=icon}
Return
Metformin improves cardiac stress tolerance and mitochondrial function during early aging
.png){kind=icon}
OA
AI
Q
J
Y
E
DOI：10.1016/j.exger.2026.113159.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Endoplasmic reticulum (ER) stress is increased in early-aged hearts. • Isoproterenol exposure impairs cardiac function in early-aged hearts, accompanied by further increases in ER stress and reduced mitochondrial function. • Chronic metformin feeding improves cardiac and mitochondrial function in early-aged hearts. • Chronic metformin treatment decreases ER stress and activates AMPK signaling in early-aged hearts.
Keywords:
Aging
Endoplasmic reticulum
Endoplasmic reticulum stress
Isoproterenol
Cardiac injury
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
4.3
Papers:
6.0K
Citations:
1.4W
Organization
Cited Papers