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MFG-E8 inhibits AT1-AA production to alleviate preeclampsia

delete2026-04-12
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PRE
AI
F
Fengfeng Xie *
Z
Zhanhua Shi
J
Jiaying Zhu
C
Cong Lin
Y
Yueqiong Zhou
F
Feng Lin *
DOI：10.1016/j.cellimm.2026.105110delete
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Abstract

Abstract

En 中文
• MFG-E8 expression is reduced in preeclampsia patients with elevated AT1-AA and trophoblast apoptosis. • MFG-E8 alleviates PE-like symptoms and inhibits AT1-AA production in LPS-induced PE rats. • MFG-E8 enhances macrophage phagocytosis of apoptotic trophoblasts in vitro.
Keywords:
MFG-E8
preeclampsia
AT1-AA
trophoblast apoptosis
macrophage phagocytosis

Journal

Cellular Immunology cover
Cellular Immunology
IF:
2.9
Papers:
3.6K
Citations:
6.1K

Organization

W
Wenzhou Medical University
Scholars:
3.3W
Papers: 1.6W
Citations: 3.0W
H
Hangzhou Normal University
Scholars:
916
Papers: 311
Citations: 1.0W
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